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You may find here a list of frequently asked questions about Cibinqo. Please consult your doctor for more details.

Frequently asked questions (FAQ)

What should I do if I missed a dose of Cibinqo?
If a dose is missed, take the dose as soon as possible.1 However, if it is less than 12 hours before the next dose, you should not take the missed dose.1 Dosing should be resumed at the regular scheduled time thereafter.1
I have mild renal impairment. Do I need to take a reduced dose of Cibinqo?

In patients with mild renal impairment (eGFR 60 to <90 mL/min), no dose adjustment is required.1 If you have a moderate renal impairment (eGFR 30 to <60 mL/min), the recommended dose of Cibinqo is 100 mg or 50 mg once daily.1 In patients with severe renal impairment (eGFR <30 mL/min), the recommended starting dose is 50 mg once daily, with a maximum daily dose of 100 mg.1

eGFR, estimated glomerular filtration rate

  • I have end-stage renal disease. Can I take Cibinqo?
Cibinqo has not been studied in patients with end-stage renal disease and hence, is currently not recommended.1
Can I take Cibinqo if I have liver disease?
No dose adjustment is required in patients with mild (Child Pugh A) or moderate (Child Pugh B) hepatic impairment.1 Cibinqo is contraindicated in patients with severe (Child Pugh C) hepatic impairment.1
Can I give my child Cibinqo?
Cibinqo is recommended for patients 18 years of age and older.1
If I am pregnant, can I continue taking Cibinqo?
Cibinqo is contraindicated during pregnancy.1 There are no or limited amount of data on the use of Cibinqo in pregnant women.1 It is also advised that women of reproductive potential should use effective contraception during treatment and for 1 month following the final dose of Cibinqo.1
Can I breast-feed while I am on Cibinqo?
Cibinqo is contraindicated during breast-feeding.1 Animal model studies have shown that Cibinqo was secreted in milk of lactating rats and hence, a risk to newborns/infants cannot be excluded.1
Can I take concomitant medications while on Cibinqo?
Inform your doctor if you are taking, have recently taken or might take any other medications, as they might affect the efficacy of Cibinqo.2 These medications could include those that treat fungal infections, depression, stroke, stomach acid reflux, heart failure, seizures, tuberculosis, prostate cancer, HIV infection, asthma, rheumatoid arthritis, and atopic dermatitis.1,2 In patients with the aforementioned conditions, Cibinqo might not be recommended, or dose adjustments might be necessary.1 Please consult your doctor for more information.
Can I drive after taking Cibinqo?
Yes, Cibinqo has no or negligible influence on the ability to drive and use machines.1
What is the difference between steroid creams and JAK inhibitors, and why is Cibinqo recommended?
Steroid creams work topically to reduce inflammation,3 while Cibinqo is an oral Janus kinase (JAK1) inhibitor that targets specific immune pathways.1,4 Unlike biologics, Cibinqo works by inhibiting JAK1, which plays a critical role in the signaling of cytokines, including IL-4 and IL-13, which drive inflammation.1,5–7
How does Cibinqo work?
By blocking the action of cytokines like IL-4 and IL-13 through the JAK/STAT pathway, Cibinqo helps reduce the signals that cause inflammation.1,4–6,8,9 This helps alleviate the symptoms of itchy and inflamed skin.1,2,5

Patient support programs

Cibinqo is subsidized by the Philanthropic Community Pharmacy of St. James' Settlement.

Contact the Philanthropic Community Pharmacy
(Reservations via phone is required)

Whatsapp: 5131 3638

Website: charityservices.sjs.org.hk

Wanchai Pharmacy

Tel: 2831 3289

Fax: 3104 3660

Address: North Wing, 8/F, St. James' Settlement, 85 Stone Nullah Lane, Wanchai (Wanchai MTR station Exit A3)

Sham Shui Po Pharmacy

Tel: 2389 9456

Fax: 3104 3621

Address: Shop No. 7, G/F, High One Grand, 188 Fuk Wing Street, Sham Shui Po, Kowloon (Cheung Sha Wan MTR station Exit A2)

Kwun Tong Pharmacy

Tel: 2116 4958

Fax: 3104 3684

Address: Shop C1, 12/F, TG Place, 10 Shing Yip Street, Kwun Tong, Kowloon (Kwun Tong MTR station Exit B1)

Fo Tan Pharmacy

Tel: 2116 1276

Fax: 3104 3601

Address: Room 917, 9/F, Shatin Galleria, 18-24 Shan Mei Street, Fo Tan, Shatin, New Territories (Fo Tan MTR station Exit B)

References
  1. CIBINQO® (abrocitinib) Prescribing Information. Pfizer Corporation Hong Kong Limited: Version January 2024.
  2. CIBINQO® (abrocitinib) Package Leaflet: Information for the patient. Pfizer Corporation Hong Kong Limited: Version January 2024.
  3. Jeziorkowska R, et al. Postepy Dermatol Alergol 2015;32:162-166.
  4. Traidl S, Werfel T. Allergologie select 2021;5:293-304.
  5. Staumont‐Sallé D, et al. JEADV Clin Pract 2023;2:518–530.
  6. Clark JD, et al. J Med Chem 2014;57:S023-S038.
  7. Guttman-Yassky E, et al. J Allergy Clin Immunol 2023;152:1394-1404.
  8. Bieber T, et al. N Engl J Med 2021;384:1101-1112.
  9. Vazquez ML, et al. J Med Chem 2018;61:1130-1152.

The information available on this website is not intended to replace consultation with a healthcare provider(s) in any manner. Please consult your healthcare provider(s) for any diagnosis and/or treatment. All decisions regarding any diagnosis and/or treatment are to be made by the healthcare provider(s) in consultation with the patient, taking into consideration the unique characteristics of the patient.

CIBINQO® is a prescription only medication. The effectiveness and side effects to medication may vary among individuals. Please consult your doctor or your pharmacist for more information.